| Short CV
| Education and Professional Experience: | 1973 | Diploma in Experimental Physics (principal advisor: Prof. Dr. E. Brun) at the UniZH | | 1973-1977 | Graduation to Dr. phil. nat. sc. (principal advisor: Prof. Dr. E. Brun) at the UniZH.Award of the Faculty. | | 1977-1979 | Research associate at the Institute of Physics of the UniZH. | | 1979-1991 | Senior research associate at the Institute of Biomedical Engineering (IBTZ) of the University of Zurich and of the Swiss Federal Institute of Technology (ETHZ). | | 1984-1985 | Research fellowship at Philips Medical Systems in Best NL, at the Philips Research Laboratories in Hamburg BRD, and at Emory University in Atlanta GA. | | 1985 | Habilitation at the Medical Faculty of the UniZH. | | 1985-1991 | Head of the MRI/MRS research division. | | since 1991 | Professor for Biomedical Engineering of UniZH. Head of the division Biophysics of IBTZ. | | 1993-2003 | "Permanent Guest Professor" of ETHZ. | | 1997 | Initiation of the International Zurich Magnetic Resonance Education Center. | | since 2001 | Chairman of the Center for MRI of UniZH and ETHZ. | | since 2002 | Member of the Board of Trustees of the International Society for Magnetic Resonance in Medicine. | | since 2003 | Full professor of ETH Zurich; director of the Institute for Biomedical Engineering |
Publications and Patents:
227 original scientific publications in international reviewed scientific journals; 59 further publications and book contributions; more than 250 publications in conference proceeding and extended abstract books.
Author or co-author of 30 scientific or technical patents.
Author of the book "Kernspin-Tomographie für die medizinische Diagnostik",
B.G. Teubner, 1985.
Honors: | 1977 | Award of the Faculty of Natural Sciences of the University of Zurich | | 1988 | Award of Georg Friedrich Götz, University of Zurich | | 1989 | Thermology Commendation Award, American Academy of Thermology | | 1993-2001 | Several medals and awards for best congress presentations | | 2001 | Günther-Laukien-Award | | | | Further Awards of the research group: | | 2001 | Philips Innovation Award (Prize winners: Klaas P. Pruessmann, Markus Weiger) | | 2001 | Ake Senning Award (Prize winner: Roger Lüchinger) | | 2003 | Award 2003 of the Swiss Soc. for Biomed. Engineering (Prize winner: Dr. Ulrike Dydak) |
Teaching activites: - Lectures on Biomedical Engineering, Biomechanics, and Magnetic Resonance in Medicine
- Practical studies in Biomedical Engineering and Medical Physics
- Seminars in Biomedical Engineering, Magnetic Resonance Imaging and in Vivo Spectroscopy, Cardiology and Heart Surgery, Neurological, Neuroradiological, and Nuclear Medicine for Functional Imaging, Stochastic Case Examples for Engineers
- International Zurich Magnetic Resonance Spectroscopy Course (block, 50 hours)
- International Zurich Magnetic Resonance Pulse Programming Course (block, 50 hours)
Memberships: - International Society for Magnetic Resonance in Medicine (board member 2002-05)
- European Society of Engineering and Medicine (executive board member 1993-99)
- European Society of Magnetic Resonance in Medicine and Biology (member of scientific program committee 2000-01)
- Society for Cardiovascular Magnetic Resonance
- Cardiovascular System Dynamics Society
- Swiss Association of Biomedical Engineering (SGBT) (president 1987-93)
- German Society of Biomedical Enginering (member of scientific advisory committee)
- Swiss Society of Radiation Biology and Medical Physics
- Swiss Association of Neuroradiology
- Zurich Physical Society
- International Federation for Medical and Biological Engineering (representative of SGBT)
- Swiss Academy of Technical Sciences (representative of SGBT)
Editorial Boards and Boards of Reviewers: Editorial Boards - Magnetic Resonance in Medicine
- Acta Neurologica Scandinavica
- Computerized Medical Imaging and Graphics
- Biomedizinische Technik
- Kardiovaskuläre Medizin
Boards of Reviewers - Circulation
- Journal of Magnetic Resonance Imaging (JMRI)
- Journal of Magnetic Resonance
- MAGMA
- Annals of Biomedical Engineering
- Journal of Biomedical Engineering
- Technology and Health Care
Reviewer of the Swiss National Science Foundation (SNF), the Austrian
Foundation for Promotion of Scientific Research, the Deutsche
Bundesministerium für Bildung und Forschung (BMBF) and the Deutsche
Forschungsgesellschaft (DFG).
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| Abstract
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Magnetic Resonance Imaging (MRI) has proven to be a powerful technology for medical
diagnoses. Due to its high soft tissue contrast and since no ionizing radiation is
applied, in today's radiological practice MRI has become one of the premier modalities
for visualizing anatomy and its changes caused by diseases. New and powerful MRI
procedures are presently being developed which enable the assessment of various
organ functions. The information gained from functional MRI not only allows for
more reliable diagnosis and therapy planning, but also contributes towards a
deeper understanding of physiology and its changes under aging and disease.
For many years, the main magnetic field strength of 1.5T has been the 'gold standard'
for clinical MRI, covering virtually all MRI applications. A couple of years ago 3.0T
field strength became widely available, and meanwhile for research also 7.0T
becomes feasible for human applications. The interest in higher field strength
is flourishing due to quite a number of technical and clinical benefits, such
as increased signal-to-noise ratio, enhanced contrast and sensitivity to the
BOLD effect, and increased chemical shift resolution. The main disadvantages
are the high sensitivity to susceptibility artifacts and the high radio
frequency absorption of the tissue causing inhomogeneous RF field distribution
and leads to high specific radio frequency absorption rates (SAR) of the tissue.
The problems can at least in part be reduced by the application of modern imaging
strategies such as parallel imaging (e.g. SENSE) and dynamic imaging (k-t BLAST,
k-t SENSE).
The new developments improve MRI of anatomical structures, significantly extend the reliability of functional MRI and show great potential for the assessment of new important functional information. They allow for the investigation of perfusion, diffusion and connectivity in the human brain, the visualization of activated brain areas, as well as assessment of brain metabolism and neuronal marker substances. By cardiovascular MRI vessel structures including coronary arteries may be visualized, blood flow and valve function may be measured, motion, perfusion and viability of heart muscle tissue as well as metabolic activities of the myocardium may be studied.
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